Foot-and-Mouth disease is a highly infectious viral disease that affects a variety of cloven-hoofed animals such as cows, pigs, and sheep. It is considered a significant threat to livestock industries worldwide due to its ability to rapidly spread and cause severe economic losses.

However, not many people are aware that prions also have the potential to cause Foot-and-Mouth disease. Prions are infectious proteins that can trigger abnormal folding of normal cellular prion proteins in the body, leading to various neurological disorders.

In the case of Foot-and-Mouth disease, researchers have found that prions can cause the disease by converting the normal prion protein into a misfolded form. This misfolded protein can then trigger a chain reaction, leading to the destruction of tissues in the hooves and mouth of affected animals.

Although prion-related Foot-and-mouth disease is relatively rare, it highlights the importance of being aware of the various pathogens that can cause this highly infectious disease. It also underscores the need for proper biosecurity measures and the implementation of effective control measures to prevent its spread.

Overall, the discovery of prion-related Foot-and-Mouth disease serves as a reminder of the complex nature of infectious diseases and the need for continued research to better understand and combat them.